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While on Avandia, I was unable to complete stress tests. Clifford Rosen, of the Maine Center for Osteoporosis, who headed the recent FDA advisory committee panel that recommended Avandia stay on the market, albeit with stronger warnings. People taking Avandia were sicker than those taking Actos, so these patients were more likely to develop heart failure, she noted. In the case of Avandia, researchers focused on the durability of the patients' blood sugar control ("glycemic durability"), even though blood sugar control is "a relatively poor surrogate for cardiovascular outcomes in type 2 diabetes," Rosen said. Initiation of Avandia in patients with established NYHA Class III or IV heart failure is contraindicated. Furthermore, discontinuation or dose reduction of Avandia must be considered.

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